Effect Of Drug Effects On The Performance System - 3109 Words

Abstract Interactions between multiple drug substances, taken in combination or simultaneously, may yield excessive risk of adverse effect. However, this increase risk is not uniform for all combinations. Some combinations may show a constant risk pattern. Collections of individual reporting of an adverse event related to adverse drug reactions have proven to be very useful. A mixture model approach is applied to AERS (adverse effect record system) data to differentiate drug combinations following different patterns. A ranking of the drug combinations is reported using their false discover rate (FDR) values. Introduction Post-approval adverse drug effects (ADEs) are a major global health concern. An estimated cost of $ 75 billion per year [1] has been attributed to these ADEs alongwith more than 2 million injuries, hospitalizations and deaths in each year in the US alone [2]. It has become an important area of research to study the effect of drug-drug interactions. For example, in treatment of cancer sometimes cytotoxic drugs are used. It becomes very important to study the effects of DDI among these drugs at all levels. Failure to recognize these effects may lead to a lot of undesired complications ranging from overdosing to undertreatment. Drug interactions can be pharmaceutical, pharmacokinetic (PK), or pharmacodynamic (PD). PK interaction occurs when a drug influences the ADME (absorption, distribution, metabolism and excretion) process of another drug. For example,Show MoreRelatedThe Legalization Of Steroids Should Be Beneficial For The World Of Sport1226 Words   |  5 Pagesnegative view for much of history. Steroids are drugs used by athletes to become stronger and achieve a strong physique. Steroids are illegal and are strongly discouraged to be used and may be seen first expressed during high school with the introduction of organized sport teams. 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